Little is known about the role of sirtuins in mediating the generation or longevity of memory t cells however given the role of sirtuins in promoting oxidative metabolism this is a potentially interesting area for further study though not specific to memory t cells sirt1 has distinct effects on pgc 1 and pgc 1 both proteins with roles in facilitating mitochondrial biogenesis and oxidative metabolism thus the return to a more oxidative metabolism in memory cells may be mediated in . Consequently sirtuins are important for cell survival stress resistance proliferation and differentiation in recent years sirtuins are increasingly recognized as crucial regulators of stem cell biology in addition to their well known roles in metabolism and aging. The sirtuins are a family of nicotinamide adenine dinucleotide nad dependent enzymes that regulate gene silencing chromosome stability and metabolism by removing acyl lysine modifications from a variety of proteins 1 the sir silent information regulator family of genes was first discovered in saccharomyces cerevisiae and was identified as necessary for repressing translation of the silent mating type loci indeed inactivation of any of these genes results in sterility 23 sir2
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